What is a common adverse reaction to corticosteroid therapy such as prednisone?

Corticosteroid therapy, including medications like prednisone, is associated with several well-documented adverse effects. Hyperglycemia is a common reaction to corticosteroids due to their impact on glucose metabolism. Corticosteroids can induce insulin resistance, leading to elevated blood sugar levels, especially in individuals with diabetes or those predisposed to hyperglycemia. This effect can result from the drug's influence on gluconeogenesis in the liver and the reduction of glucose uptake in peripheral tissues.

While other adverse effects of corticosteroid therapy do exist, such as weight gain and osteoporosis, hyperglycemia is particularly prevalent and often observed soon after initiation of treatment. Thus, it is essential for practitioners to monitor blood glucose levels in patients receiving corticosteroid therapy and manage any potential hyperglycemia appropriately. This understanding is crucial for providing optimal care to patients who require corticosteroids for their underlying conditions.