What is a common symptom of opioid withdrawal?

Yawning, lacrimation, and mydriasis are commonly associated symptoms of opioid withdrawal due to the physiological changes that occur when an individual becomes dependent on opioids and then suddenly ceases their use. During withdrawal, the body reacts to the absence of the drug, which leads to a hyperactive state of the autonomic nervous system.

Yawning occurs as a response to increased levels of anxiety and agitation, while lacrimation reflects the body's withdrawal from the sedative effects of opioids, resulting in an overproduction of tears. Mydriasis, or dilation of the pupils, is another hallmark of opioid withdrawal and is a result of increased sympathetic nervous system activity once the depressant effects of opioids are no longer present. Collectively, these symptoms represent a physiological rebound effect as the body readjusts to normal function without the influence of opioids.

These manifestations align with the overall pattern of signs and symptoms that one would expect during the withdrawal phase, marking them as key indicators in diagnosing opioid dependence and withdrawal.