Which of the following is part of the diagnostic criteria for hyperemesis gravidarum?

In the context of hyperemesis gravidarum, the correct answer focuses on a significant weight loss that is indicative of the condition's severity. Weight loss greater than 5% of prepregnancy weight is a key diagnostic criterion for hyperemesis gravidarum. This level of weight loss suggests that the patient is experiencing severe nausea and vomiting to the extent that it is impacting nutrition and hydration, which can have serious implications for both the mother and the developing fetus.

Hyperemesis gravidarum is characterized by persistent vomiting that typically does not improve with usual dietary adjustments. It significantly affects the mother's ability to maintain her nutritional status, reflected in the weight loss criterion. This distinguishes it from ordinary morning sickness, which is less severe and does not typically lead to substantial weight loss.

Other indicators of hyperemesis gravidarum may include electrolyte imbalances and dehydration, which can be assessed through various clinical evaluations—notably not through increased appetite or normal urinary ketones, both of which would not align with the expected presentation of the condition.